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Effect of gefitinib on autophagy and apoptosis in A549 cells following suppression of the PI3K/AKT/mTOR pathway by LY294002. (A) Acridine orange staining revealing LY294002 induces autophagy in A549 cells, however no synergism was observed following combined treatment with gefitinib and LY294002. (B) Flow cytometry showing that LY294002 promotes apoptosis in A549 cells, however no synergism was observed following combined treatment with gefitinib and LY294002.
