Table I.
Characteristics of RCC patients and KIF18A protein and mRNA expression detected by immunohistochemistry and reverse transcription-quantitative polymerase chain reaction, respectively.
| KIF18A protein | ||||||||
|---|---|---|---|---|---|---|---|---|
| Characteristic | n | − | + | ++ | +++ | P-value | KIF18A mRNA | P-value |
| Renal cell carcinoma | 273 | 29 | 126 | 72 | 46 | 2.30±0.29 | ||
| Non-cancerous renal tissue | 182 | 139 | 32 | 11 | 0 | <0.05 | 0.62±0.08 | <0.05 |
| Gender | >0.05 | >0.05 | ||||||
| Male | 149 | 17 | 69 | 39 | 24 | 2.27±0.28 | ||
| Female | 124 | 12 | 57 | 33 | 22 | 2.33±0.29 | ||
| Age | >0.05 | >0.05 | ||||||
| <60 years | 152 | 16 | 69 | 42 | 25 | 2.30±0.26 | ||
| ≥60 years | 121 | 13 | 57 | 30 | 21 | 2.28±0.28 | ||
| Tumor size | <0.05 | <0.05 | ||||||
| ≤7 cm | 147 | 23 | 103 | 14 | 7 | 1.53±0.21 | ||
| >7 cm | 126 | 6 | 23 | 58 | 39 | 3.18±0.35 | ||
| Histological grade | <0.05 | <0.05 | ||||||
| G1 | 145 | 23 | 97 | 21 | 4 | 1.22±0.18 | ||
| G2 | 90 | 6 | 29 | 46 | 9 | 2.57±0.29 | ||
| G3 | 38 | 0 | 0 | 5 | 33 | 5.88±0.68 | ||
| Tumor stage | <0.05 | <0.05 | ||||||
| I | 147 | 23 | 103 | 14 | 7 | 1.34±0.15 | ||
| II | 47 | 4 | 17 | 21 | 5 | 2.30±0.29 | ||
| III | 44 | 2 | 5 | 16 | 21 | 3.64±0.41 | ||
| IV | 35 | 0 | 1 | 21 | 13 | 4.59±0.52 | ||
| Metastasis | <0.05 | <0.05 | ||||||
| Absent | 242 | 29 | 125 | 54 | 34 | 1.98±0.22 | ||
| Present | 31 | 0 | 1 | 18 | 12 | 4.76±0.53 | ||
Protein expression is shown as staining intensity, and mRNA expression is shown as mean ± standard deviation. RCC, renal cell carcinoma; KIF18A, kinesin family member 18A.