Table 3.

Diagnostic performance of UroVysion FISH by patient subgroup

Risk factor	Subgroup	Method	Sensitivity			Specificity			P-value
			Estimate (%)	LCI	UCI	Estimate (%)	LCI	UCI
Overall	None	GLMM	39	31	46	82	79	85	<0.001
		GEE	38	32	45	77	75	80	<0.001
Age	40	GLMM	17	11	26	93	89	96	<0.001
	50		23	16	31	90	86	93
	60		31	24	39	86	83	89
	70		40	33	47	81	77	84
	80		49	41	57	74	68	79
	40	GEE	20	14	28	89	85	92	<0.001
	50		25	19	33	86	82	89
	60		32	26	39	81	78	84
	70		39	33	46	76	73	79
	80		47	40	54	70	65	74
Smoking	Never	GLMM	25	18	34	89	86	92	<0.001
	Former		46	38	54	77	72	81
	Current		41	28	55	80	71	87
	Never	GEE	26	34	85	85	81	88	<0.001
	Former		44	52	72	72	68	75
	Current		40	51	76	76	68	82
Gender	Female	GLMM	28	20	36	88	84	92	<0.001
	Male		44	36	52	78	74	82
	Female	GEE	28	22	36	84	80	87	<0.001
	Male		43	37	37	73	69	77
Race	White	GLMM	40	33	47	81	77	85	0.219
	Black		31	21	42	87	81	91
	Other		37	17	61	83	65	93
	White	GEE	39	33	46	76	73	79	0.160
	Black		31	23	41	82	76	87
	Other		35	17	58	80	61	91
Indication	Hematuria	GLMM	26	19	35	88	84	92	<0.001
	Cancer		46	38	54	76	71	80
	Other		28	19	40	87	80	92
	Hematuria	GEE	29	22	37	83	79	86	<0.001
	Cancer		44	38	52	71	67	75
	Other		31	22	41	82	75	87