. Author manuscript; available in PMC: 2017 Feb 1.

Published in final edited form as: J Clin Psychiatry. 2016 Feb;77(2):212–220. doi: 10.4088/JCP.14m09505

Table 2.

Cross-Sectional Analysis of Depressive Symptoms by Cholesterol Quintiles

	Unadjusted			Multivariable-adjusted ^a

	Odds Ratio	95% CI	p-value	Odds Ratio	95% CI	p-value
LDL Cholesterol			0.23^b			0.39^b

175+ mg/dL	reference			reference
153 – 174 mg/dL	0.92	0.82-1.05	0.21	0.97	0.85-1.12	0.70
134 - 152 mg/dL	0.90	0.79-1.01	0.083	0.90	0.79-1.04	0.14
114 – 133 mg/dL	0.89	0.79-1.01	0.064	0.89	0.78-1.03	0.11
< 114 mg/dL	0.98	0.87-1.11	0.78	0.97	0.85-1.12	0.69

HDL Cholesterol			<0.0001^b			0.95^b

66+ mg/dL	reference			reference
56 – 65 mg/dL	1.13	1.00-1.28	0.05	1.05	0.91-1.20	0.52
50 - 55 mg/dL	1.18	1.04-1.35	0.012	1.01	0.88-1.18	0.85
43 – 49 mg/dL	1.21	1.07-1.38	0.0026	1.01	0.87-1.16	0.94
< 43 mg/dL	1.43	1.26-1.62	<0.0001	1.04	0.90-1.21	0.60

Total Cholesterol			0.063^b			0.38^b

260+ mg/dL	reference			reference
236 – 259 mg/dL	0.95	0.84-1.08	0.46	0.98	0.85-1.12	0.73
216 – 235 mg/dL	0.88	0.77-0.99	0.04	0.89	0.77-1.02	0.09
195 - 215 mg/dL	0.95	0.84-1.08	0.42	0.92	0.80-1.06	0.24
< 195 mg/dL	1.05	0.93-1.19	0.43	0.99	0.86-1.13	0.83

Triglycerides			*0.0022^b*			0.08^b

185+ mg/dL	reference			reference
136 – 184 mg/dL	1.00	0.89-1.13	0.96	1.07	0.93-1.22	0.35
106 – 135 mg/dL	0.95	0.84-1.07	0.38	1.04	0.91-1.20	0.56
80 – 105 mg/dL	0.81	0.72-0.92	0.0014	0.88	0.76-1.02	0.09
< 80 mg/dL	0.86	0.76-0.98	0.022	0.98	0.84-1.14	0.78

adjusted for age, WHI trial arm, ethnicity, U.S. region, marital status, income, education, insurance coverage, heart disease, stroke, peripheral artery disease, diabetes, cancer, thyroid disease, colitis, cholesterol-lowering medications, systolic blood pressure, diastolic blood pressure, BMI, smoking status, alcohol consumption, and leisure-time physical activity

linear trend across quintiles