Table 3.
Hazard Analysis for 11-year Follow-up
| Unadjusted | Multivariable-adjusteda | |||||
|---|---|---|---|---|---|---|
|
| ||||||
| Hazards Ratio | 95% CI | p-value | Hazards Ratio | 95% CI | p-value | |
| LDL Cholesterol | ||||||
|
| ||||||
| 175+ mg/dL | reference | reference | ||||
| 153-174 mg/dL | 1.10 | 0.93-1.30 | 0.27 | 1.20 | 1.00-1.43 | 0.055 |
| 134-152 mg/dL | 1.06 | 0.90-1.25 | 0.50 | 1.16 | 0.97-1.39 | 0.11 |
| 114-133 mg/dL | 1.06 | 0.90-1.25 | 0.49 | 1.09 | 0.90-1.30 | 0.40 |
| <114 mg/dL | 1.25 | 1.07-1.47 | 0.0055 | 1.25 | 1.05-1.49 | 0.014 |
|
| ||||||
| HDL Cholesterol | ||||||
|
| ||||||
| 66+ mg/dL | reference | reference | ||||
| 56 – 66 mg/dL | 1.04 | 0.89-1.21 | 0.63 | 1.00 | 0.85-1.18 | 0.99 |
| 50 - 56 mg/dL | 1.04 | 0.89-1.22 | 0.61 | 0.92 | 0.78-1.10 | 0.38 |
| 43 – 50 mg/dL | 1.00 | 0.85-1.16 | 0.95 | 0.82 | 0.69-0.98 | 0.03 |
| < 43 mg/dL | 1.09 | 0.92-1.28 | 0.31 | 0.81 | 0.67-0.98 | 0.029 |
|
| ||||||
| Total Cholesterol | ||||||
|
| ||||||
| 260+ mg/dL | reference | reference | ||||
| 236 – 259 mg/dL | 0.99 | 0.84-1.18 | 0.94 | 1.09 | 0.91-1.31 | 0.33 |
| 216 – 235 mg/dL | 1.10 | 0.94-1.30 | 0.23 | 1.17 | 0.98-1.40 | 0.08 |
| 195 - 215 mg/dL | 1.05 | 0.89-1.24 | 0.58 | 1.07 | 0.89-1.28 | 0.48 |
| < 195 mg/dL | 1.15 | 0.98-1.36 | 0.08 | 1.11 | 0.93-1.33 | 0.23 |
|
| ||||||
| Triglycerides | ||||||
|
| ||||||
| 185+ mg/dL | reference | reference | ||||
| 136 – 184 mg/dL | 0.93 | 0.80-1.09 | 0.39 | 0.957 | 0.81-1.13 | 0.61 |
| 106 – 135 mg/dL | 0.91 | 0.78-1.07 | 0.25 | 1.004 | 0.85-1.19 | 0.97 |
| 80 – 105 mg/dL | 0.92 | 0.78-1.07 | 0.28 | 1.041 | 0.87-1.24 | 0.65 |
| < 80 mg/dL | 0.80 | 0.68-0.95 | 0.0089 | 0.962 | 0.79-1.17 | 0.69 |
Adjusted for WHI trial arm, BMI, lipid-lowering medication, blood pressure, smoking status, coronary heart disease, stroke, peripheral artery disease, age, U.S. region, ethnicity, marital status, health insurance, alcohol consumption, leisure-time physical activity, cancer, income, education, diabetes, thyroid disease, and colitis