Table 2.
Insulin resistance calculated using the quantitative insulin sensitivity check index
| 4 W | 8 W | 12 W | 16 W | 20 W | 24 W | |
|---|---|---|---|---|---|---|
| MF | N.D. | 0.227 | 0.139 | N.D. | N.D. | 0.413 |
| 0.064 | N.D. | 0.348 | N.D. | 0.445 | 0.12 | |
| N.D. | 0.381 | 0.193 | N.D. | N.D. | 0.249 | |
| N.D. | N.D. | 0.416 | 0.315 | N.D. | 0.777 | |
| N.D. | N.D. | 0.672 | N.D. | N.D. | 0.083 | |
| HFCD | N.D. | 0.22 | 0.089 | 0.058 | 0.026 | 0.045 |
| 0.2002 | 0.206 | 0.047 | 0.034 | 0.026 | 0.025 | |
| 0.3954 | 0.168 | 0.067 | 0.034 | 0.057 | 0.025 | |
| 0.0705 | N.D. | 0.081 | 0.027 | 0.034 | 0.018 | |
| 0.1384 | N.D. | 0.046 | 0.079 | 0.037 | 0.030 | |
| MF + DEN | 1.047 | N.D. | 0.579 | N.D. | N.D. | 0.2916 |
| N.D. | N.D. | N.D. | N.D. | N.D. | 0.116 | |
| N.D. | 0.916 | N.D. | 0.642 | N.D. | 0.131 | |
| N.D. | 0.916 | N.D. | N.D. | N.D. | 0.153 | |
| N.D. | 0.159 | N.D. | 9.101 | 0.245 | N.D. | |
| HFCD + DEN | 1.047 | 0.0808 | 0.016 | 0.072 | 0.033 | 0.026 |
| N.D. | 0.1167 | 0.031 | 0.054 | 0.063 | 0.020 | |
| 0.1026 | 0.377 | 0.030 | 0.025 | 0.069 | 0.034 | |
| 0.0826 | 0.315 | 0.048 | 0.314 | 0.201 | 0.031 | |
| 0.172 | 0.173 | 0.036 | 0.022 | 0.055 | 0.037 |
The quantitative insulin sensitivity check index = 1/log (fasting insulin) + log (fasting glucose). A value < 0.3 indicates insulin resistance; values from 0.348 to 0.430 are normal, and values ≥ 3.0 indicate high insulin sensitivity (type 1 diabetes mellitus). Index values < 0.3 (insulin resistance) are in bold. Each group contained five mice. W weeks, MF standard diet, HFCD high-fat choline-deficient diet, DEN diethylnitrosamine, N.D not determined