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Expression of Sp1 and HIF1α in situ tumors of HCC patients. Sp1 was expressed predominantly in the nuclei of HCC cells of the tumor regions, and HIF1α was expressed in the nuclei and plasma. The expression levels of Sp1 and HIF1α were markedly higher in (A) patients who had succumbed to disease compared with (B) surviving patients. HIF1α, hypoxia-inducible factor 1α; Sp1, transcription factor specificity protein 1.
