Table III.
Multivariate logistic regression analyses for the combination of Sp1 and HIF1α on cancer-specific survival in hepatic cancer.
| Independent variable | HR (95% CI) | P-value |
|---|---|---|
| Sex (male vs. female) | 0.786 (0.468–1.320) | 0.362 |
| Relative family cancer history | 0.939 (0.544–1.619) | 0.820 |
| Surgery (extended vs. partial excision) | 1.213 (0.716–2.055) | 0.473 |
| Histology grade (G3/4 vs. G1/2) | 1.428 (0.844–2.416) | 0.185 |
| Pathologic tumor stage (T3/4 vs. T1/2) | 0.767 (0.401–1.467) | 0.423 |
| AJCC 7th stage (III/IV vs. I/II) | 1.883 (0.882–4.019) | 0.102 |
| Expression of Sp1 and HIF1α | ||
| Both markers <2,000 | 1.000 (reference) | |
| Either one ≥2,000 | 3.270 (1.843–5.803) | 0.001 |
| Both markers ≥2,000 | 5.420 (2.767–10.616) | 0.001 |
HR, hazard ratio; CI, confidence interval; AJCC, American Joint Committee on Cancer; HIF1α, hypoxia-inducible factor 1α; Sp1, transcription factor specificity protein 1.