Table IV.
The association between Sp1 and HIF1α according to immunohistochemistry and survival in 50 patients with hepatic cancer.
| Outcomesa | Outcomesb | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Alive | Cancer mortality | Alive | Cancer mortality | ||||||
| Tumor tissue | N | % | N | % | Tumor tissue | N | % | N | % |
| Sp1 | HIF1α | ||||||||
| − | 4 | 16.0 | 1 | 4.0 | − | 6 | 24.0 | 1 | 4.0 |
| + | 15 | 60.0 | 1 | 4.0 | + | 16 | 64.0 | 2 | 8.0 |
| ++ | 3 | 12.0 | 5 | 20.0 | + | 2 | 8.0 | 4 | 16.0 |
| +++ | 3 | 12.0 | 18 | 72.0 | +++ | 1 | 4.0 | 18 | 72.0 |
The staining intensity was scored as 0 (negative, -), 1 (weak, +), 2 (medium, ++) or 3 (strong, +++).
a
The correlations between Sp1 expression and vital status in patients (dead/alive) was analyzed by χ2 test, P=0.001
b
The correlations between HIF1α expression and vital status in patients (dead/alive) was analyzed by χ2 test, P=0.001. HIF1α, hypoxia-inducible factor 1α; Sp1, transcription factor specificity protein 1.