Table 1.
Gene | SNP | Allele (1/2) | Amino acid change | Other name | AILIa | Non-AILIa | RAF | P valueb | HWE | ||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
11 | 12 | 22 | 11 | 12 | 22 | AILI | Non-AILI | ALLELIC | DOM | REC | AILI | Non-AILI | |||||
ABCB1 | rs1045642 | C/T | I1145I | C3435T | 12 | 15 | 3 | 151 | 196 | 67 | 0.65 | 0.60 | 0.50 | 0.70 | 0.60 | 0.59 | 0.80 |
rs2032582 | T, A/G | S,T893A | G2677 T/A | 2 | 16 | 12 | 138 | 191 | 85 | 0.67 | 0.44 | 0.00068 | 0.0017 | 0.020 | 0.27 | 0.21 | |
G, A/T | A,T893S | 15 | 14 | 1 | 158 | 193 | 63 | 0.73 | 0.61 | 0.073 | 0.24 | 0.10 | 0.29 | 0.75 | |||
G, T/A | A,S893T | 26 | 4 | 0 | 283 | 114 | 17 | 0.93 | 0.82 | 0.031 | 0.039 | 0.62 | 0.70 | 0.21 | |||
rs1128503 | T/C | G412G | C1236T | 15 | 12 | 3 | 146 | 197 | 71 | 0.70 | 0.59 | 0.10 | 0.12 | 0.45 | 0.79 | 0.74 | |
ABCG2 | rs2231142 | C/A | Q141K | C421A | 12 | 15 | 3 | 195 | 180 | 39 | 0.35 | 0.31 | 0.57 | 0.57 | 0.76 | 0.59 | 0.78 |
CYP2C9 | rs1799853 | C/T | R144C | CYP2C9*2 | 30 | 0 | 0 | 412 | 0 | 0 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 |
rs1057910 | A/C | I359L | CYP2C9*3 | 28 | 2 | 0 | 393 | 20 | 0 | 0.03 | 0.02 | 0.66 | 0.65 | 1.00 | 0.85 | 0.61 | |
CYP2C19 | rs4244285 | G/A | P227P | CYP2C19*2 | 16 | 9 | 5 | 197 | 180 | 36 | 0.32 | 0.31 | 0.88 | 0.58 | 0.18 | 0.09 | 0.57 |
rs4986893 | G/A | W212X | CYP2C19*3 | 27 | 3 | 0 | 321 | 86 | 6 | 0.95 | 0.88 | 0.14 | 0.16 | 1.00 | 0.77 | 0.93 | |
CYP3A4 | rs12721627 | C/G | T185S | CYP3A4*16 | 29 | 1 | 0 | 405 | 8 | 0 | 0.02 | 0.01 | 0.47 | 0.47 | 1.00 | 0.93 | 0.84 |
rs28371759 | T/C | L292P | CYP3A4*18 | 29 | 1 | 0 | 399 | 14 | 0 | 0.98 | 0.98 | 1.00 | 1.00 | 1.00 | 0.93 | 0.73 | |
CYP3A5 | rs776746 | G/A | – | CYP3A5*3 | 18 | 11 | 1 | 223 | 165 | 26 | 0.78 | 0.74 | 0.54 | 0.57 | 1.00 | 0.66 | 0.54 |
SLCO1B1 | rs2306283 | G/A | N130D | SLCO1B1*1B | 14 | 12 | 4 | 185 | 179 | 50 | 0.67 | 0.66 | 1.00 | 0.85 | 0.77 | 0.58 | 0.51 |
rs4149056 | T/C | V174A | SLCO1B1*5 | 18 | 11 | 1 | 306 | 95 | 13 | 0.22 | 0.15 | 0.14 | 0.13 | 1.00 | 0.66 | 0.10 | |
UGT1A1 | rs4148323 | G/A | G71R | UGT1A1*6 | 25 | 5 | 0 | 281 | 118 | 15 | 0.92 | 0.82 | 0.075 | 0.10 | 0.61 | 0.62 | 0.55 |
rs8175347 | (TA)6/(TA)7 | – | UGT1A1*28 | 23 | 7 | 0 | 332 | 76 | 6 | 0.12 | 0.11 | 0.83 | 0.64 | 1.00 | 0.47 | 0.49 |
Abbreviation: AILI atorvastatin-induced liver injury, RAF risk allele frequency, ALLELIC Allelic model, Dom Dominant model, REC Recessive model, HWE Hardy–Weinberg equilibrium
aAILI, N = 30; Non-AILI, N = 414
bThe lowest significant P value after Bonferroni correction among three models is shown in bold (P < 0.0011)