Table 1.

Association of 15 functional SNPs in eight candidate genes with atorvastatin-induced liver injury

Gene	SNP	Allele (1/2)	Amino acid change	Other name	AILIa			Non-AILIa			RAF		P valueb			HWE
					11	12	22	11	12	22	AILI	Non-AILI	ALLELIC	DOM	REC	AILI	Non-AILI
ABCB1	rs1045642	C/T	I1145I	C3435T	12	15	3	151	196	67	0.65	0.60	0.50	0.70	0.60	0.59	0.80
	rs2032582	T, A/G	S,T893A	G2677 T/A	2	16	12	138	191	85	0.67	0.44	0.00068	0.0017	0.020	0.27	0.21
		G, A/T	A,T893S		15	14	1	158	193	63	0.73	0.61	0.073	0.24	0.10	0.29	0.75
		G, T/A	A,S893T		26	4	0	283	114	17	0.93	0.82	0.031	0.039	0.62	0.70	0.21
	rs1128503	T/C	G412G	C1236T	15	12	3	146	197	71	0.70	0.59	0.10	0.12	0.45	0.79	0.74
ABCG2	rs2231142	C/A	Q141K	C421A	12	15	3	195	180	39	0.35	0.31	0.57	0.57	0.76	0.59	0.78
CYP2C9	rs1799853	C/T	R144C	CYP2C9*2	30	0	0	412	0	0	1.00	1.00	1.00	1.00	1.00	1.00	1.00
	rs1057910	A/C	I359L	CYP2C9*3	28	2	0	393	20	0	0.03	0.02	0.66	0.65	1.00	0.85	0.61
CYP2C19	rs4244285	G/A	P227P	CYP2C19*2	16	9	5	197	180	36	0.32	0.31	0.88	0.58	0.18	0.09	0.57
	rs4986893	G/A	W212X	CYP2C19*3	27	3	0	321	86	6	0.95	0.88	0.14	0.16	1.00	0.77	0.93
CYP3A4	rs12721627	C/G	T185S	CYP3A4*16	29	1	0	405	8	0	0.02	0.01	0.47	0.47	1.00	0.93	0.84
	rs28371759	T/C	L292P	CYP3A4*18	29	1	0	399	14	0	0.98	0.98	1.00	1.00	1.00	0.93	0.73
CYP3A5	rs776746	G/A	–	CYP3A5*3	18	11	1	223	165	26	0.78	0.74	0.54	0.57	1.00	0.66	0.54
SLCO1B1	rs2306283	G/A	N130D	SLCO1B1*1B	14	12	4	185	179	50	0.67	0.66	1.00	0.85	0.77	0.58	0.51
	rs4149056	T/C	V174A	SLCO1B1*5	18	11	1	306	95	13	0.22	0.15	0.14	0.13	1.00	0.66	0.10
UGT1A1	rs4148323	G/A	G71R	UGT1A1*6	25	5	0	281	118	15	0.92	0.82	0.075	0.10	0.61	0.62	0.55
	rs8175347	(TA)6/(TA)7	–	UGT1A1*28	23	7	0	332	76	6	0.12	0.11	0.83	0.64	1.00	0.47	0.49

Abbreviation: AILI atorvastatin-induced liver injury, RAF risk allele frequency, ALLELIC Allelic model, Dom Dominant model, REC Recessive model, HWE Hardy–Weinberg equilibrium

^aAILI, N = 30; Non-AILI, N = 414

^bThe lowest significant P value after Bonferroni correction among three models is shown in bold (P < 0.0011)