Table 2.
Association of haplotypes consisting of three SNPs of ABCB1 with atorvastatin-induced liver injury
| rs1128503 | rs2032582 | rs1045642 | Number of carriers | P valueb | |
|---|---|---|---|---|---|
| AILIa (%) | Non-AILIa (%) | ||||
| T | T | T | 15 (50.0) | 237 (57.2) | 0.45 |
| C | G | C | 11 (36.7) | 158 (38.2) | 1.00 |
| T | G | C | 16 (53.3) | 126 (30.4) | 0.014 |
| C | A | C | 4 (13.3) | 128 (30.9) | 0.060 |
| T | G | T | 3 (10.0) | 25 (6.0) | 0.45 |
| T | T | C | 0 (0.0) | 24 (5.8) | 0.39 |
| C | G | T | 2 (6.7) | 11 (2.7) | 0.22 |
| T | A | C | 0 (0.0) | 5 (1.2) | 1.00 |
| C | T | T | 0 (0.0) | 2 (0.5) | 1.00 |
| C | T | C | 0 (0.0) | 2 (0.5) | 1.00 |
Abbreviation: AILI atorvastatin-induced liver injury
aAILI, N = 30; Non-AILI, N = 414
bThe significant P value after Bonferroni correction is less than 0.005