Table I.
Notch pathway phenotypes involved in liver development and regeneration in mouse models.
| Author, year | Disrupted gene | Phenotype | (Ref.) |
|---|---|---|---|
| Croquelois et al, 2005 | Notch1 | Nodular regenerative hyperplasia, disruption of homeostasis of hepatic | (23) |
| and Dill et al, 2012 | sinusoids and stimulation of pre-and postnatal bile duct proliferation | (24) | |
| Geisler et al, 2008 | Notch2 | Impaired intrahepatic bile duct development | (25) |
| Chen et al, 2012 | Notch3 | Regulation of HSC activation. Interruption of Notch3 may be an anti-fibrotic strategy in hepatic fibrosis | (26) |
| Krebs et al, 2000 | Notch4 | Severe defects in angiogenic vascular remodeling | (27) |
| Hofmann et al, 2010 | JAG1 | Exhibition of Alagille syndrome, characterized by a paucity of intrahepatic bile ducts | (28) |
| Jiang et al, 1998 | JAG2 | Perinatal death | (29) |
| Redeker et al, 2013 | Dll1 | Stimulation of neuronal differentiation, lethal at embryonic day 11.5, severe somite patterning defects, hyperplastic CNS | (30) |
| Turnpenny et al, 2003 | Dll3 | Severe abnormalities in somitogenesis and recessive skeletal abnormalities in spondylocostal dysosotosis | (32) |
| Gale et al, 2004 | Dll4 | Arteriovenous shunting, severe vascular remodeling defects | (33) |
| and Djokovic et al, 2010 | (31) |
JAG, Jagged; Dll, Delta-like-ligand; HSC, hematopoietic stem cells; CNS, central nervous system.