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. 2016 Jun 13;13:147. doi: 10.1186/s12974-016-0610-y

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© The Author(s). 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 4 — Effect of CTB on mRNA expression of cytokines in microglia/macrophage isolated from the ischemic hemisphere. a CTB dose-dependently downregulated the level of IL-1β mRNA expression in microglia/macrophage isolated from the ischemic hemisphere at 24 h. b CTB dose-dependently downregulated the level of TNF-α mRNA expression in microglia/macrophage isolated from the ischemic hemisphere at 24 h. Bars represent mean ± SD (n = 8); *p < 0.05 vs MCAO group, and #p < 0.05 vs CTB-L group