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. 2016 May 13;12(1):250–256. doi: 10.3892/ol.2016.4569

Figure 4.

Figure 4.

Effect of SV on IGF-1 receptor signaling pathway. (A) SV decreases the expression of IGF-1R in a dose-dependent manner. *P<0.001 vs. untreated control cells. (B) SV and IGF-1 stimulated the expression of P-ERK. However, SV suppressed the expression of P-ERK induced by IGF-1 treatment. *P<0.001 vs. untreated control cells; **P<0.05 vs. untreated control cells. (C) SV suppressed IGF-1-induced Akt activation. * P<0.001, 100 nM IGF-1 vs. untreated control cells; **P<0.05, 10 µM SV + 100 nM IGF-1 vs. untreated control cells; ***P<0.001, 10 µM SV+100 nM IGF-1 vs. IGF-1 100 nM. SV, simvastatin; IGF-1, insulin-like growth factor 1; ERK, extracellular signal-regulated kinase; P-ERK, phosphorylated-ERK.