Table 2.
Comparison of the synergism elicited by glycopyrronium/indacaterol vs. aclidinium/formoterol combinations in human isolated bronchi stimulated by EFS at 10 Hz
| Glycopyrronium/indacaterol | Aclidinium/formoterol | P | |
|---|---|---|---|
| AUC | |||
| 0-1 h | 20.22 ± 8.38 | 27.39 ± 3.51 | NS |
| 0-3 h | 72.65 ± 18.72 | 108.25 ± 10.12 | ** |
| 0-6 h | 127.26 ± 28.81 | 175.07 ± 16.86 | ** |
| 0-9 h | 164.64 ± 41.88 | 186.40 ± 29.87 | NS |
| 0-12 h | 175.43 ± 61.55 | 159.25 ± 53.19 | NS |
| Onset (T1/2, min) | 18.30 ± 9.30 | 15.5 ± 3.5 | NS |
| Emax (plateau, %) | 25.93 ± 9.41 | 42.94 ± 7.56 | *** |
| Duration of synergism (h) | 9:00 ± 0:11 | 6:00 ± 0:12 | *** |
AUC(0-t): area under the curve for specific time intervals; EFS: electrical field stimulation; NS: not significant (P > 0.05). Data are expressed as mean ± SEM from experiments performed using samples from n = 3 different subjects. **P < 0.01 and ***P < 0.001 (statistical significance assessed by two-way ANOVA)