Table 2.

Sensitivity and specificity of molecular parameter

Parameter	CAD	HPP	SSA	SSA‐D	TSA
BRAF mutation
n	(2/118)	(85/116)	(145/179)	(31/41)	(28/62)
Chi‐square test	p < 0.001	p < 0.001	p < 0.001	p = 0.010	p = 0.057
Sensitivity	0.017	0.733	0.810	0.756	0.452
Specificity	0.274	0.485	0.567	0.453	0.421
KRAS mutation
n	(28/118)	(16/116)	(6/179)	(1/41)	(23/62)
Chi‐square test	p = 0.002	0.747	p < 0.001	p = 0.021	p < 0.001
Sensitivity	0.237	0.138	0.003	0.024	0.387
Specificity	0.879	0.850	0.792	0.842	0.885
MLH1 hypermethylation
Mean ± SD (%)	3.0 ± 2.4	3.0 ± 2.7	4.5 ± 4.4	20.1 ± 21.3	5.7 ± 11.2
n with cut‐off > 17%	(0/95)	(0/66)	(2/106)	(13/33)	(3/52)
Chi‐square test	p = 0.008	p = 0.036	p = 0.071	p < 0.001	p = 0.816
Sensitivity	0.000	0.000	0.019	0.394	0.057
Specificity	0.930	0.937	0.935	0.984	0.950
CDKN2A hypermethylation
Mean ± SD (%)	8.4 ± 9.0	11.2 ± 14.5	13.7 ± 14.7	22.4 ± 13.3	17.8 ± 13.9
n with cut‐off > 17%	(16/95)	(13/65)	(34/108)	(22/33)	(27/50)
Chi‐square test	p < 0.001	p = 0.017	p = 0.770	p < 0.001	p < 0.001
Sensitivity	0.189	0.200	0.315	0.667	0.540
Specificity	0.624	0.646	0.669	0.709	0.710
Intraepithelial lymphocytes
n with cut‐off > 10/HPF	(20/118)	(12/116)	(55/179)	(34/41)	(27/62)
Chi‐square test	p = 0.002	p < 0.001	p < 0.001	p < 0.001	p = 0.004
Sensitivity	0.169	0.103	0.307	0.829	0.435
Specificity	0.686	0.668	0.776	0.766	0.740