Table 2.
Drug effects on hemorheological parameters in k-carrageenan-induced rat tail thrombosis model (n = 10)
| Groups | WBV (mPa.s) | PV (mPa.s) | ||
|---|---|---|---|---|
| Low shear rate (5 s−1) | Medium shear rate (100 s−1) | High shear rate (200 s−1) | ||
| Control | 18.56 ± 3.03## | 4.63 ± 0.77## | 3.55 ± 0.79## | 1.55 ± 0.28# |
| Model | 27.75 ± 3.27 | 6.74 ± 0.78 | 5.24 ± 0.63 | 2.04 ± 0.47 |
| CMC-Na | 26.42 ± 2.66 | 6.87 ± 0.62 | 5.22 ± 0.52 | 1.97 ± 0.25 |
| Aspirin | 22.75 ± 3.57* | 6.21 ± 0.62 | 5.21 ± 0.35 | 1.39 ± 0.13** |
| Eugenol | 28.69 ± 2.93 | 6.87 ± 0.72 | 5.52 ± 0.79 | 1.63 ± 0.25* |
| AEE L | 20.03 ± 2.75** | 5.38 ± 0.78** | 4.58 ± 0.67* | 1.32 ± 0.12** |
| AEE M | 22.60 ± 2.28** | 5.48 ± 0.86** | 4.74 ± 0.52 | 1.68 ± 0.61 |
| AEE H | 22.25 ± 3.60** | 5.14 ± 0.69** | 4.63 ± 0.62 | 1.50 ± 0.14** |
| Combination | 27.45 ± 2.90 | 6.58 ± 1.06 | 5.28 ± 0.63 | 2.19 ± 0.30 |
After the last measurement of rat tail thrombosis length at 48 h, 0.8 mL of whole blood and 0.5 mL of plasma were collected for hemorheological parameter tests. Data are expressed as mean ± SD. # P < 0.05, ## P < 0.01 compared with model group. *P < 0.05, **P < 0.01 compared with CMC-Na group. WBV whole blood viscosity, PV plasma viscosity. AEE L: AEE 18 mg/kg; AEE M: 36 mg/kg; AEE H: AEE 72 mg/kg; Combination: combination of aspirin and eugenol (molar ratio 1:1)