TABLE 2.
Characteristics of 11 nontransformable S. pneumoniae isolates
| Strain | Serotype | MLST | CSP type | Dpn type | Loss-of-function mutations |
Polymorphism(s) |
||||
|---|---|---|---|---|---|---|---|---|---|---|
| Gene | Position | Change(s) | Gene(s) | Position(s) | Change(s) | |||||
| TH880 | 8 | 53 | CSP-1 | II | comGC | 3–4 | Single nucleotide A insertion; frameshifting | radA | 797 | G→T |
| TH2594 | 10A | 8481 | CSP-1 | II | None | None | None | celB | 1087 | G→A |
| dprA | 580 | G→C | ||||||||
| comGB | 7, 9, 677 | G→A, G→A, G→A | ||||||||
| TH2774 | 9V | 1263 | CSP-1 | II | None | None | None | comA | 1793 | C→T |
| comD | 575 | C→T | ||||||||
| celA | 272, 607–609 | C→T, GGC→ACT | ||||||||
| celB | 1501, 1507 | C→T, G→A | ||||||||
| comFA | 1108 | G→T | ||||||||
| TH2782 | 23F | 342 | CSP-1 | I | None | None | None | coiA | 881 | C→T |
| TH2813 | 19A | 4317 | CSP-4 | I | comD | 789 | Frameshifting | comA | 2117 | C→T |
| comE | 722 | Frameshifting | comFA | 338 | A→G | |||||
| comX2 | 75 | G→A, stop codon | cclA | 196, 198 | G→A, C→T | |||||
| TH2861 | 6B | 4645 | CSP-1 | II | comE | 565 | C→T, stop codon | comA | 776 | C→T |
| celB | 24, 943, 946 | C→A, C→T, G→C | ||||||||
| comFA | 338, 412, 1063 | A→G, A→C, C→T | ||||||||
| TH2863 | 19F | 6993 | CSP-1 | I | comE | 730 | Insertion of 1,544-bp insertion element in the 3′ coding region, frameshifting | None | None | None |
| TH2875 | 19F | 6887 | CSP-1 | II | None | None | None | comB | 481 | G→A |
| TH2880 | 1 | 2296 | CSP-2 | II | None | None | None | celB | 202, 204, 212, 980 | G→C, T→G, A→C, C→T |
| coiA | 139 | C→T | ||||||||
| TH2893 | 1 | 2296 | CSP-1 | II | comE | 676 | G→T, stop codon | celB | 202, 204, 212, 980 | G→C, T→G, A→C, C→T |
| coiA | 139 | C→T | ||||||||
| TH2904 | 14 | 876 | CSP-1 | I | None | None | None | None | None | None |