TABLE 2.
Mutations in the fully sequenced genomes of the Biysk isolates
| Genome region | Nucleotide (amino acid) mutation | Genome(s) of Biysk isolates harboring mutationa | Previous report(s) of same mutation in Sabin 2-derived virusesb |
|---|---|---|---|
| 5′ UTR | A145→U | PT1-1, PT1-2 | |
| U156→C | PT3, PT4 | 20, 21, 22, 23, 24 | |
| A248→G | C-1 | 10, 25, 26 | |
| U344→C | PT1-1, PT1-2 | 21, 22 | |
| U398→C | PT2, PT3, PT4-0, PT4 | 8, 10, 20, 21, 22, 23, 24, 26, 27, 28, 29 | |
| A481→G | All | 8, 10, 20, 21, 22, 23, 24, 25, 26, 27, 28 | |
| U690→C | C-2 | 20 | |
| A718→G | C-1 | ||
| U722→C | C-1 | 8, 27, 30 | |
| U744→C | C-2 | 21, 23, 30 | |
| VP4 | A888→G | C-1 | |
| C909→U | C-1 | 10, 27 | |
| VP2 | U984→C | PT1-2 | 26 |
| A1042→G (N30→D) | C-2 | ||
| C1059→U | Main group | 31 | |
| C1080→U | PT3-1 | ||
| U1125→C | C-1 | 22 | |
| C1161→U | PT3-1 | ||
| C1281→U | PT3, PT4-0, PT4 | 10 | |
| U1317→C | C-2 | ||
| U1392→C | C-2 | ||
| A1407→G | Main group | 10 | |
| A1429→G (S159→G) | C-2 | 32 | |
| G1462→A (A170→T) | Main group | 33 | |
| A1468→G (N172→D) | PT3-1 | ||
| A1512→G | C-1 | 8 | |
| C1623→U | PT3-1 | ||
| A1758→G | PT1-1 | ||
| VP3 | G1855→A (V30→I) | Main group | |
| C1935→U | PT1-2 | 10 | |
| A1997→G (H77→R) | C-1 | 10 | |
| C1998→A (H77→Q) | PT3-1 | ||
| A2005→G (T80→A) | PT3-1 | 10, 22, 29 | |
| C2020→U (L85→F) | Main group and C-2 | ||
| G2188→A (A141→T) | C-1 | ||
| C2193→U | PT1-2 | 8 | |
| A2223→U | PT3, PT4-0, PT4 | 10 | |
| G2250→A | PT3, PT4-0, PT4 | 10, 28 | |
| C2310→U | PT1-2 | 8 | |
| VP1 | A2492→C (D4→A) | Main group | |
| A2494→U (M5→L) | PT1-2 | 34 | |
| Deletion of nt 2497–2499 (I6) | C-1 | ||
| C2550→U | PT1-2 | 29, 35 | |
| A2628→G | C-2 | 10 | |
| U2909→C (I143→T) | All | 10, 24, 25, 27, 28, 29, 33, 34, 36 | |
| C3279→U | Main group | 36 | |
| G3343→A (D288→N) | PT1-1, PT1-2 | 10 | |
| 2A | A3459→G | Main group | 7 |
| A3491→G (N36→S) | PT1-2 | ||
| A3559→G (T59→A) | PT3, PT4-0, PT4 | ||
| U3597→C | PT1-1, PT1-2 | 21 | |
| C3639→G | C-1 | ||
| A3726→G | PT1-2 | ||
| 2B | C3966→U | PT3-1 | 10, 37 |
| U4044→A | PT1-2 | 38 | |
| 2C | U4216→C | C-2 | |
| A4335→G | C-2 | 39 | |
| C4653→U | Main groupc | ||
| G4909→A (A263→T) | PT1-1 | ||
| G5063→A (R314→K) | PT1-2 | ||
| 3A | G5121→U (Q4→H) | C-2 | |
| G5168→A (C20→Y) | C-1 | ||
| A5223→G | PT1-2 | 21, 24 | |
| U5238→C | PT1-2 | ||
| C5365→U (H86→Y) | PT2, PT3-1, C-1 | ||
| 3B | C5418→U | C-2 | |
| 3C | A5457→G | C-2 | 7 |
| U5532→C | All | ||
| C5559→U | PT3, PT4-0, PT4 | ||
| A5592→G | PT3-1 | ||
| A5625→G | C-1 | ||
| U5640→C | PT1-1 | ||
| A5823→G | PT1-1, PT1-2 | ||
| A5852→G (N139→S) | PT3-1 | ||
| G5949→A | PT3, PT4-0, PT4, PT1-2 | 25, 40 | |
| C5970→U | PT3, PT4-0, PT4 | ||
| A5985→G | PT1-2 | ||
| 3D | U6075→C | PT2, PT3-1, C-1 | 24, 28, 39 |
| G6084→A | PT3-1 | ||
| G6142→A (D53→N) | PT1-2 | ||
| A6156→G | C-2 | ||
| C6438→U | All | ||
| U6618→C | PT3, PT4-0, PT4 | ||
| C6789→U | All | ||
| C7071→U | Main group | ||
| U7119→C | PT1-1, PT1-2, C-2 | AJ544513d | |
| C7326→U | PT1-2 | ||
| 3′ UTR | G7405→A | PT3, PT4-0, PT4 | 10, 20, 22, 26, 28, 29, 37, 38, 39 |
a
The “main group” represents all fully sequenced genomes, except PT1-1, PT1-2, and C-2.
b
Reference numbers in boldface reported on the relevant mutation in more than one isolate.
c
C/U heterogeneity was detected at this position in the PT1 genome.
d
GenBank accession number.