TABLE 3.
Mutations in the partially sequenced derivatives of Sabin 2 polioviruses isolated from healthy contacts during the Biysk outbreaka
| Genome region | Additional nucleotide (amino acid) mutation compared with PT1 sequence | Strain genome(s) | Genome(s) of fully- sequenced strain(s) with same mutation |
|---|---|---|---|
| VP3 | G1827→A | C-4 | |
| A1997→G (H77→R) | C-10, C-13, C-14 | C-1 | |
| A2157→G | C-7 | ||
| A2223→U | C-19 | ||
| G2250→A | C-19 | PT3, PT4-0, PT4 | |
| U2364→C | C-13 | PT3, PT4-0, PT4 | |
| VP1 | G2608→A (A43→T) | C-16 | |
| A2707→G (T76→A) | C-9 | ||
| A2901→U | C-18 | ||
| U3178→A (S233→T) | C-13 | ||
| U3204→C | C-7 | ||
| G3237→C | C-13 | ||
| 5′ part of 2Ab | C3445→U | C-6, C-11 |
a
All of these isolates harbored the whole set of mutations present in this region of the PT1 RNA.
b
Nucleotides 3385 to 3460.