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. Author manuscript; available in PMC: 2017 Feb 1.
Published in final edited form as: J Neurooncol. 2015 Sep 18;126(3):385–393. doi: 10.1007/s11060-015-1939-2

Figure 1.

Figure 1

Radiation cooperates with PLX4720 to reduce clonogenic survival in BRAF V600E-mutant but not BRAF WT glioma cells. (A) BRAF V600E glioma cell lines; (B) BRAF WT glioma cell line; (C) Dose Enhancement Ratio (DER) for each cell line calculated at 90% survival level. PLX4720 (500 nM) was administered 24 hour before radiation (0, 2, 4, 6 Gy). Surviving fractions, shown as mean + SE (quadruplicate samples), were normalized to plating efficiency for each cell line. Radiation alone: solid line. Radiation + PLX4720: dashed line. XRT: radiation therapy. Clonogenic survival data points were fitted to a linear quadratic mathematical model.