Figure 6.

Effect of c-Jun N-terminal kinase 1/2 induction on cell growth and viability. Active MKK7 treatment at the highest concentration tested for 48 h resulted in a significant dose-dependent decrease in cell growth and viability, which were more prominent in SCC25 than in SCC9 cells. Cell growth changes were significant at the highest concentration tested, compared with the control, in both cell lines (SCC25 P=0.039; SCC9 P=0.044), while cell viability changes were significant at both concentrations, compared with the control, in the SCC25 cell line (5μΜ P=0.041, 10μΜ P=0.03). Data are presented as the average ± standard deviation of four replicates. MKK7, mitogen-activated protein kinase kinase 7.