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O-linked N-acetylglucosamine glycosylation increases anaplastic thyroid carcinoma cell proliferation. Thia-G and pCMV-Flag-OGT treatment enhanced the cell proliferation of 8305C and THJ-11T8 cells, while OGT silencing with shOGT inhibited cell proliferation. Mean ± standard error of the mean. *P<0.05, **P<0.01 vs. ctrl (Student's t-test). Ctrl, control; Thia-G, Thiamet-G; OGT, O-linked N-acetylglucosamine transferase; sh, short hairpin RNA.
