. Author manuscript; available in PMC: 2016 Jun 14.

Published in final edited form as: J Allergy Clin Immunol. 2010 Nov 4;126(6):1141–8.e7. doi: 10.1016/j.jaci.2010.08.047

Table 4. Unadjusted and adjusted effects of infant acetaminophen use on childhood asthma and related phenotypes.

Odds ratios:
Outcome	N	Unadj.	(95% CI)	P	Adj.^*	(95% CI)	P
Asthma	7735	1.19	(1.08, 1.32)	<.001	1.11	(1.00, 1.23)	.046
Wheezing	7821	1.20	(1.08, 1.34)	<.001	1.12	(1.00, 1.25)	.045
Eczema	7809	1.09	(1.00, 1.18)	.06	1.05	(0.97, 1.15)	.23
Atopy	6092	1.15	(1.05, 1.26)	.002	1.14	(1.04, 1.25)	.005
Geometric mean ratios:
Outcome	N	Unadj.	(95% CI)	P	Adj.^*	(95% CI)	P
BHR slope	4118	1.07	(1.00, 1.15)	.06	1.04	(0.97, 1.12)	.3
Total IgE	4812	0.99	(0.93, 1.06)	.88	0.97	(0.90, 1.03)	.32
Arithmetic mean differences:
Outcome	N	Unadj.	(95% CI)	P	Adj.*	(95% CI)	P
Adjusted FVC (SDs)	6327	-0.01	(-0.04, 0.03)	.7	-0.01	(-0.04, 0.03)	.69
Adjusted FEV₁ (SDs)	6231	0.00	(-0.03, 0.04)	.8	0.01	(-0.03, 0.04)	.66
Adjusted FEF_25-75 (SDs)	6327	0.00	(-0.03, 0.04)	.81	0.01	(-0.03, 0.04)	.69

Adjusted for maternal factors in pregnancy (smoking, infections, anxiety score, acetaminophen and antibiotic use, alcohol intake); other maternal factors (educational level, housing tenure, financial difficulties, body mass index, ethnicity, age, parity, history of asthma, eczema, rhinoconjunctivitis, migraine); sex of child, season of birth, multiple pregnancy, gestational age, birthweight, head circumference, birth length; postnatal factors (breast feeding, day care, pets, damp/mould, environmental tobacco smoke exposure, number of younger siblings, infant antibiotic use, BMI at age 7).