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. Author manuscript; available in PMC: 2017 Apr 1.
Published in final edited form as: Circ Cardiovasc Genet. 2016 Mar 11;9(2):136–146. doi: 10.1161/CIRCGENETICS.115.001323

Figure 6.

Figure 6

E141G-CaM has no effect on Ca2+ sparks and SR Ca2+ content. (A) Representative line-scan images of Ca2+ sparks in permeabilized mouse ventricular myocytes in CaM-free (vehicle), WT-CaM, and E141G-CaM in the presence of AIP2 (1μM). (B) Average Ca2+ spark frequency and (C) Ca2+ spark amplitude. Data are mean ± SD (n=20). (D) Line scan (top) and (bottom) line plot (red arrow) examples of SR Ca2+ content evaluated by 10 mM caffeine-evoked Ca2+ transient in CaM-free (vehicle), WT-CaM, and E141G-CaM in the presence of AIP2 (1μM). (E) Average SR Ca2+ content. Data are mean ± SD (n=4).