Table 3.

Whole exome sequencing variant summary

SUDY Case Number	1	2	3	4	5	6	7	8	9	10	11	12	13	14	AVG
All Genes
Missense	12599	11834	13320	14642	14825	11369	12942	14249	11210	11897	9105	12197	9358	9133	12049±1915
Splice Site	60	63	60	79	67	58	59	69	59	58	36	59	46	43	59±11
Nonsense	118	106	114	126	129	80	93	138	86	74	51	101	59	62	95±28
INDELS (frame-shift)	238	216	231	249	264	219	219	245	209	232	150	226	208	169	220±30
INDELS (inframe)	324	279	325	321	347	282	282	326	286	279	204	303	275	227	290±39
Sudden Death Genes (n=117)
Missense	91	65	78	104	89	76	91	89	87	71	56	59	61	59	77±15
Splice Site	1	0	0	1	0	0	0	1	0	0	0	0	1	0	0.28±0.47
Nonsense	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0
INDELS (frame-shift)	2	1	2	0	0	0	0	1	0	0	0	0	0	0	0.42±0.76
INDELS (inframe)	1	2	1	1	2	1	2	2	1	2	2	2	1	1	1.5±0.52
Number of Putative Mutations (absent in controls)	0	0	0	0	0	0	0	1	1	2	1	1	1	1	0.57±0.65

Abbreviations: AVG, average; INDELS, insertion/deletions.