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. Author manuscript; available in PMC: 2016 Jun 14.
Published in final edited form as: Heart Rhythm. 2014 Oct 31;12(2):419–422. doi: 10.1016/j.hrthm.2014.10.035

Figure 2. Familial Electrocardiograms, WES Filtering Strategy, and Mutation Confirmation.

Figure 2

(A) Pedigree of family utilized for WES, including ECGs for the mother and father of the proband, showing normal corrected QT intervals. (B) Filtering strategy utilized for WES, separated by inheritance pattern, to include filtering for sporadic inheritance (left) and recessive inheritance (right). Some variants were identified in both sequencing strategies; please see Table 1 for more information regarding the identified variants. (C) DNA Sanger sequencing confirmation of the p.D130G mutation in the proband (lower) and the p.D130G mutation’s absence in the parents (upper), supporting a sporadic inheritance pattern.