Figure 1.

T and B cells are not required for Brucella-induced focal inflammation. A–B, Flow cytometry was performed on joints from naive C57BL/6 and interferon γ (IFN-γ)^−/− mice or from C57BL/6 and IFN-γ^−/− mice 28 days after intraperitoneal infection with approximately 1 × 10⁵ colony-forming units (CFUs) of Brucella melitensis 16 M (4–5 mice/group). Within a cell type, mean values with the same letter are not significantly different from each other (P < .05). Error bars depict standard errors of the mean (SEMs). C–D, Wild-type (WT), μMT^−/−, and Rag1^−/− mice (all on a C57BL/6 background) were infected intraperitoneally with approximately 1 × 10⁵ CFUs of Brucella melitensis 16 M and treated with anti-IFN-γ (5–10 mice/group). Incidence of paw swelling (C) and average clinical scores (D) were recorded over time. Error bars depict SEMs.