Figure 5.

CXCR2 mediates Brucella-induced inflammation in interferon γ (IFN-γ)^−/− mice. IFN-γ^−/− and IFN-γ^−/−/CXCR2^−/− mice (on a C57BL/6 background; 4–7 mice/group) were infected intraperitoneally with approximately 1 × 10⁵ colony-forming units (CFUs) of B. melitensis. The incidence of paw swelling (A), clinical scores (B), and mean swelling (C) were recorded over time. Colonization of the joints and spleen was determined on day 18 and 25 after infection (D). *P < .05 as compared to IFN-γ^−/− mice. Data in panels A–C are representative of 3 independent experiments. Error bars depict standard errors of the mean.