Figure 4.

Regulatory T-cell density is associated with virus shedding and titer. A, Herpes simplex virus type 2 (HSV-2) titer during acute lesion and posthealing time points. Each line depicts an individual patient. All subjects had no evidence of HSV-2 DNA after week 2. B and C, The correlation between viral titer (measured at the acute lesion stage) and CD4⁺Foxp3⁺ (B) and total CD4⁺ cells (C) by linear regression analysis. D, Association between CD4⁺Foxp3⁺ (top), CD4⁺ (middle), and CD8⁺ (bottom) T-cell density and HSV-2 shedding from all biopsy specimens in the data set. Natural log–transformed cell density is plotted according to viral shedding status: ●, shedding; ▪, no shedding. The horizontal line represents the mean log density. P values are shown.