Figure 2.

Change in immune activation markers over 48 weeks by change in body mass index (BMI; calculated as the weight in kilograms divided by the height in meters squared) and antiretroviral treatment initiation. β-coefficients represent the incremental change in each inflammatory marker per increase in BMI. The underweight group is indicated by yellow, normal weight by blue, and overweight/obese groups by red. All analyses are adjusted for age, sex, country, study treatment arm, screening CD4⁺ T-cell count, plasma baseline log₁₀ human immunodeficiency virus type 1 RNA load, and prevalent tuberculosis. Abbreviations: CI, confidence interval; CRP, C-reactive protein; CXCL-10, interferon γ–inducible protein 10; IFN-γ, interferon γ; IL-6, interleukin 6; IL-18, interleukin 18; sCD14, soluble CD14; TNF-α, tumor necrosis factor α.