Fig 4. Optimal bactericidal activity of MC, but not neutrophils, is dependent upon IFNγ.
C57BL/6 (A, B) or IFNγ-/- (B) mice were infected with L. pneumophila and at 2 days after infection the indicated cell types were isolated, lysed and the lysates cultured on selective bacterial culture plates to determine the number of L. pneumophila CFU per 104 cells in each cell population. In B, lines connect data points from individual experiments using the same bacterial inoculum. Each point represents the results from one experiment where lungs from 4–5 mice were pooled. *. P < 0.05. In A all comparisons to AM group. In B, the fold change refers to the ratio of the averages of the two groups.