Table 1. Clinical characteristics of uncomplicated pregnancy control (n = 19), gestational hypertensive (n = 9), and preeclampsia (n = 9) groups; for comparison of soluble Sdc1 in gestational age-matched, 2nd trimester maternal plasma.
| Uncomplicated Pregnancy (n = 19) | Gestational Hypertension (n = 9) | Preeclampsia (n = 9) | |
|---|---|---|---|
| Age (years) | 24 (20–35) | 22 (19–36) | 24 (17–41) |
| BMI pre-pregnancy (kg/m2) | 29 (23–36) | 26 (22–37) | 31 (23–45) |
| Gestational weeks at venipuncture | 19.7 (17.7–23.9) | 19.9 (17.7–24.4) | 19.4 (18.4–22.3) |
| Gestational weeks at delivery | 40 (29–42) | 40 (38–41) | 38 (30–40) a,c |
| Early gestational BP (<20wks.): | |||
| Systolic (mm Hg) | 114 (99–126) | 119 (111–137) | 116 (109–130) |
| Diastolic (mm Hg) | 69 (59–80) | 73 (64–86) | 70 (68–78) |
| Pre-delivery BP: | |||
| Systolic (mm Hg) | 126 (104–138) | 144 (141–163) b | 148 (141–193) a |
| Diastolic (mm Hg) | 73 (55–80) | 90 (78–94) b | 97 (89–114) a |
| Birth weight percentile | 75 (30–91) | 41 (16–60) b | 23 (1–93) a |
| Uric acid (mg/dL) | — | 4.8 (3.7–5.4) | 5.9 (5.1–8.7) c |
| Cigarette smokers (n, %) | 0 (0%) | 0 (0%) | 0 (0%) |
| Race (n, % Black) | 9 (47%) | 4 (44%) | 5 (56%) |
| Infant Sex (n, %Female) | 10 (53%) | 4 (44%) | 3 (33%) |
| Preeclampsia with preterm delivery (n, %) | 4 (44%) | ||
| Preeclampsia with SGA infants (n,%) | 2 (22%) |
Continuous variables are displayed as median (range); categorical variables are displayed as n (%). BMI, body mass index; BP, blood pressure. Early gestational BP: mean of all gestational blood pressures obtained prior to 20 weeks’. Preeclampsia with preterm delivery: preeclampsia with delivery before 37 weeks of gestation. Preeclampsia with SGA infants: preeclampsia with small-for-gestational-age (SGA) defined as birthweight percentile less than 10th.
a Significant difference between preeclamptics and controls (P<0.05)
b Significant difference between gestational hypertensives and controls (P<0.05)
c Significant difference between preeclamptics and gestational hypertensives (P<0.05)
Group differences in continuous variables evaluated by Kruskal-Wallis with post hoc Dunn’s test; Categorical variables by Fisher’s Exact Test.