Table 2. Custom-designed baits used for Sureselect target enrichment of 15 CRC susceptibility genes.

Chr	Genbank reference	Gene	Total target region (kb)	Chromosome		Total area covered (kb)	% of total target area	% repeated sequences
				Start	End
1	NM_001128425.1	MUTYH	19,2	45791914	45811142	10,7	56%	33%
2	NM_002354.2	EPCAM	25,9	47591286	47617165	13,4	52%	55%
2	NM_000251.2	MSH2	88,1	47625262	47713360	26,1	30%	58%
2	NM_000179.2	MSH6	31,9	48005220	48037084	14,5	45%	42%
2	NM_000534.4	PMS1	101,5	190643810	190745354	48,4	48%	41%
3	NM_000249.3	MLH1	60,5	37034840	37095335	23,2	38%	52%
5	NM_002439.4	MSH3	230,3	79945293	80175633	80,6	35%	53%
5	NM_000038.5	APC	146,7	112038217	112184935	60,6	41%	47%
7	NM_000535.5	PMS2	36,7	6012370	6049037	9,8	27%	59%
10	NM_004329.2	BMPR1a	176,5	88511395	88687944	52,7	30%	58%
10	NM_000314.4	PTEN	103,3	89628194	89731531	41,8	40%	49%
14	NM_001040108.1	MLH3	43,8	75477466	75521235	21,3	49%	41%
16	NM_003502.3	AXIN1	73	334439	407464	39,1	54%	36%
17	NM_004655.3	AXIN2	118,5	63521684	63640183	65	55%	34%
18	NM_005359.5	SMAD4	62,8	48551582	48614409	31,7	50%	39%

Baits were designed against 15 CRC susceptibility genes. Target region spans the entire genomic region, including 5 kb upstream and 3 kb downstream of the gene. Repeated sequences are not covered by custom-designed baits.