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. 2016 Jun 14;11(6):e0154582. doi: 10.1371/journal.pone.0154582

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© 2016 Chen et al

This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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Fig 2 — A. 5’ joining points of deletion: The X-axis represents the nucleotide position along the mitochondrial genome divided into 1kb nucleotide increments, and the Y-axis represents the average percentage deletion part in aging samples (ND) or patients with Alzheimer’s disease (AD). The percentage of regional deletion within each kb is calculated by dividing the total number of deletions (5’ breakpoint) within 1kb by the total deletions in the sample. B. 3’ joining points of deletion: The X-axis represents the nucleotide position along the mitochondrial genome divided into 1kb nucleotide increments, and the Y-axis represents the average deletion part in aging samples (ND) or patients with Alzheimer’s disease (AD). The percentage of regional deletion within each kb is calculated by dividing the total number of deletions (3’ breakpoint) within 1kb by the total deletions in the sample. AD samples have more 3’ breakpoint at 16kb (28.8% in AD compared 13.7% in ND, P = 0.02).