Table 2.
Cohort demographics and comparison between genotype positive and genotype negative patients
Genotype positive | Genotype negative | p value | |
---|---|---|---|
N (%) | 101 (51) | 97 (49) | |
Sex M/F, n (% male) | 56/45 (55) | 52/45 (54) | 0.9 |
Age at diagnosis (years) | 41.9± 17.9 | 58.3± 18.0 | <0.001 |
FH HCM, n (%) | 55 (54) | 17 (18) | <0.001 |
FH SCD, n (%) | 40 (40) | 24 (25) | 0.03 |
FH HCM and/or SCD, n (%) | 26 (26) | 7 (7) | <0.001 |
Hx of hypertension, n (%) | 23 (23) | 38 (39) | 0.01 |
Symptoms at diagnosis, n (%) | 75 (74) | 79 (81) | 0.2 |
MLVWT (mm) | 21.3 ±7.5 | 18.3 ±4.4 | <0.001 |
LVOT gradient (mm Hg) | 62.4±39.5 | 71.2±33.9 | 0.2 |
Septal shape, n (%) | |||
Sigmoid | 37 (37) | 63 (65) | <0.001 |
Reverse curve | 37 (37) | 11 (11) | <0.001 |
Neutral | 12 (12) | 9 (9) | 0.7 |
Apical | 10 (10) | 10 (10) | 0.8 |
Myectomy, n (%) | 46 (46) | 43 (44) | 0.9 |
ICD, n (%) | 42 (42) | 13 (13) | <0.001 |