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pSMAD 1/5/8 inhibition reduces MP induced-mesenchymal morphology and MMP-2 activation. ESC aggregates were treated with pSMAD 1/5/8 inhibitor (LDH-193189) from day 3– day 14 of differentiation. (A) Morphology changes were evaluated by H&E staining on day 14 and (B) the expression levels of pro and active forms of MMP-2 were analyzed by zymography on days 7 and 10 of differentiation.
