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. 2016 Jun 7;12:917–925. doi: 10.2147/TCRM.S89215

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© 2016 Lorusso. This work is published and licensed by Dove Medical Press Limited

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Intensity of emesis according to HEC and MEC.

Notes: Half-life (hours) of approved 5-HT3-RA and NK1-RA is reported. Half-life of first generation of 5-HT3-RA ranges from 5 hours to 6 hours for ondansetron and from 5 hours to 12 hours for granisetron.

Abbreviations: CINV, chemotherapy-induced nausea and vomiting; HEC, highly emetogenic chemotherapy; 5-HT3-RA, 5-HT3 receptor antagonist; MEC, moderately emetogenic chemotherapy; NEPA, netupitant/palonosetron; NK1-RA, NK1 receptor antagonist; h, hours.