Table 4.

Number of doses of antiemetic drugs required for the prophylaxis of CINV in patients receiving MEC

Chemotherapy regimen	Antiemetic regimen	References	Antiemetic drug	Day 1	Day 2	Day 3	Day 4	Day 5	N of doses
MEC-AC	NEPA + DEX	39,44	NEPA	X					2
MEC non-AC			DEX	X
MEC-AC	APR + 5-HT3-RA + DEX	40,47	APR	X	X	X			5
MEC non-AC			Ondansetron	X
			DEX	X
MEC non-ACa	FOS + 5-HT3-RA + DEX	49	FOS	X					3
			Granisetron	X
			DEX	X
MEC-AC	ROL + 5-HT3-RA + DEX	51	ROL	XX					8
MEC non-AC			Granisetron	X	XX	XX
			DEX	X

Notes: Calculations of number of doses are based on pivotal studies of approved NK1-RAs.39,40,44,47,49,51

^aOnly non-AC, MEC study is available for FOS.

Abbreviations: AC, anthracycline plus cyclophosphamide; APR, aprepitant; CINV, chemotherapy-induced nausea and vomiting; DEX, dexamethasone; FOS, fosaprepitant; 5-HT3-RA, 5-HT3 receptor antagonist; MEC, moderately emetogenic chemotherapy; N, number; NEPA, netupitant/palonosetron; NK1-RAs, NK1 receptor antagonists; ROL, rolapitant.