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. 2016 Jun 8;11:2675–2683. doi: 10.2147/IJN.S104374

Figure 4.

Figure 4

Inflammatory response in the injection site.

Notes: Representative images of footpad subcutaneous tissue at 3 days (A, D, and G, scale bars =100 µm) and 5 days (B, E, and H, scale bars =100 µm; and C, F, and I, scale bars =20 µm) post-administration of naked pDNA (A–C), PEISH nanoparticles (D–F) or PEISH-HC nanoparticles (G–I). Arrowheads indicate the presence of infiltrating inflammatory cells.

Abbreviations: pDNA, plasmid DNA; PEISH, thiolated poly(ethylene imine); HC, carboxylic fragment of tetanus toxin.