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. 2016 Jun 8;11:2695–2709. doi: 10.2147/IJN.S99028

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© 2016 Zorzetto et al. This work is published and licensed by Dove Medical Press Limited

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Scheme of production of microstructure systems.

Notes: Different techniques were developed depending on the materials used. Manufacturing processes starting from traditional synthetic polyesters begin from a solution of the polymer and drug or from an oil/water suspension of such a solution. Then they are processed through different methods (spray-drying, flow-focused method, evaporation, sonication, double-syringe mixing, and a second emulsion) to obtain microspheres.

Abbreviations: PEG, polyethylene glycol; sol, solution; PVA, polyvinyl alcohol.