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A. Demonstration of acellular osteochondral Puzzle Constructs cast on 3D printed interlocking porous bases: side-view of individual osteochondral construct consisting of (a) gel-region and (b) bone-region (left); paired osteochondral constructs (center); assembly of nine bases (right). Scale bars: 1 mm. B. Demonstration of in situ assembly and trimming of puzzle constructs (42 days cultured) in a canine cadaver femur defect.
