Table 2.

Comparison of change in global, articular and bone layer T2 relaxation times (mean [95% confidence interval]) over 48 months of the cartilage compartments of the knees between the group with stable weight and weight loss groups. An increase in T2 values indicates a worsening of cartilage degradation¹.

Parameter	Compart ment		stable weight	5-10% weight loss	P- value 5-10% weight loss vs. stable weight group	>10% weight loss	P-value >10% weight loss group vs. stable weight group
Global ΔT2 (in ms)	all compart ments	Baseline mean T2 (ms)	32.4 [32.1, 32.7]	32.5 [32.0, 32.7]	0.8	32.7 [32.2, 33.2]	0.3
		Change in mean T2 (ms)	1.0 [0.8, 1.1]	0.8 [0.6, 1.1]	0.6	0.6 [0.4, 1.0]	0.3
	LF	Baseline mean T2 (ms)	36.3 [35.9, 36.7]	35.8 [35.3, 36.3]	0.3	36.4 [35.8, 37.1]	0.7
		Change in mean T2 (ms)	1.5 [1.2, 1.8]	1.3 [0.8, 1.7]	0.7	1.2 [0.7, 1.6]	0.7
	LT	Baseline mean T2 (ms)	27.1 [26.8, 27.3]	27.3 [27.0, 27.7]	0.3	27.4 [26.7, 28.0]	0.4
		Change in mean T2 (ms)	1.2 [1.0, 1.6]	1.0 [0.7, 1.3]	0.2	1.0 [0.8, 1.2]	0.3
	MF	Baseline mean T2 (ms)	39.7 [39.3, 40.1]	39.2 [38.7, 39.7]	0.2	39.0 [38.6, 39.5]	0.8
		Change in mean T2 (ms)	0.6 [0.2, 1.0]	0.8 [0.4, 1.1]	0.6	0.4 [0.0, 0.9]	0.5
	MT	Baseline mean T2 (ms)	29.1 [28.9, 29.4]	29.3 [28.8, 29.6]	0.6	29.3 [28.7, 29.9]	0.6
		Change in mean T2 (ms)	1.1 [0.8, 1.4]	0.8 [0.4, 1.0]	0.2	−0.3 [−0.9, 0.4]	<0.001
	PAT	Baseline mean T2 (ms)	30.5 [30.1, 30.9]	30.7 [30.1, 31.1]	0.7	31.3 [30.5, 32.1]	0.08
		Change in mean T2 (ms)	0.9 [0.5, 1.3]	0.5 [0.3, 1.1]	0.2	0.4 [0.02, 1.0]	0.3
Articular Layer ΔT2 (in ms)	all compart ments	Baseline mean T2 (ms)	35.3 [35.0, 35.6]	35.2 [34.8, 35.6]	0.9	35.6 [35.0, 36.2]	0.5
		Change in mean T2 (ms)	1.1 [0.8, 1.3]	1.0 [0.6, 1.3]	0.6	0.9 [0.3, 1.5]	0.3
	MT	Baseline mean T2 (ms)	32.4 [32.1, 32.7]	32.4 [32.1, 32.7]	0.1	32.4 [32.1, 32.7]	0.7
		Change in mean T2 (ms)	1.3 [0.9, 1.6]	0.9 [0.4, 1.3]	0.1	0.0 [−0.2, 0.7]	<0.001
	PAT	Baseline mean T2 (ms)	33.1 [32.7, 33.6]	33.4 [32.8, 33.9]	0.5	34.0 [33.1, 34.9]	0.1
		Change in mean T2 (ms)	0.9 [0.4, 1.3]	0.5 [0.0, 1.0]	0.3	0.5 [0.0, 1.1]	0.8
Bone Layer ΔT2 (in ms)	all compart ments	Baseline mean T2 (ms)	29.6 [29.3, 29.8]	29.5 [29.2, 29.8]	0.9	29.4 [29.1, 30.2]	0.3
		Change in mean T2 (ms)	1.0 [0.7, 1.1]	0.9 [0.6, 1.1]	0.7	0.4 [0.0, 0.8]	0.03
	MT	Baseline mean T2 (ms)	26.4 [26.1, 26.7]	26.5 [26.1, 26.8]	0.9	26.5 [26.0, 27.0]	0.7
		Change in mean T2 (ms)	1.0 [0.6, 1.2]	0.8 [0.4, 1.2]	0.06	−0.2 [−0.5, 0.3]	<0.001
	PAT	Baseline mean T2 (ms)	27.9 [27.5, 28.2]	27.9 [27.4, 28.2]	0.9	28.6 [27.9, 29.4]	0.2
		Change in mean T2 (ms)	1.0 [0.6, 1.3]	0.5 [0.3, 0.8]	0.07	0.2 [−0.5, 0.5]	0.04

¹The associations between ΔT2 relaxation times and weight loss (5-10% weight loss and >10% weight loss) over 48 months were assessed using linear regression models adjusting for age, sex, baseline BMI and baseline KL score.

BMI, body mass index; LF, lateral femur; LT, lateral tibia; MF, medial femur; MT, medial tibia; PAT, patella.