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. 2016 Apr 15;37(7):627–639. doi: 10.1002/humu.22973

Figure 1.

Figure 1

Illustration of the MaxEntScan sliding window approach. A: BRCA1 cDNA reference sequence from 4,865 to 4,873, highlighting nucleotide C4868 in exon 16. B: Sliding a MaxEntScan donor window across an innocuous possible substitution, c.4868C>T. C: Sliding a MaxEntScan donor window across the de novo donor creating substitution c.4868C>G; note the relatively high MaxEntScan donor score at the sixth frame of the sliding window. D: MaxEntScan evaluation of the intron 16 splice donor; note that this score is actually lower than the score of c.4868C>G.