Table 3.

Qualitative Z‐Score Ranges and Probabilities of Pathogenicity for Potential Damage to Reference Splice Junctions

Qualitative category	MES z‐score range	Alpha	95% CI	Number of variants used	Prior probability
Improved	Score improved versus reference sequence	0.00	(0.00, 0.08)	46	0.04
Minimal	Donor: z > 0	0.00	(0.00, 0.08)	24	0.04
	Acc: z > 0.5
Moderate	Donor: −2 ≤ z ≤ 0	0.34	(0.15, 0.55)	66	0.34
	Acc: −1.5 ≤ z ≤ 0.5
High	Donor: z < −2	0.97	(0.82, 1.00)	94	0.97
	Acc: z < −1.5