Table 1.

Fourteen SNPs that are eSNPs for genes that are co-expressed with IL6R and also have a reproducible association with asthma risk.

			Co-expression with IL6R			Ferreira, 2014		GABRIEL
No.	eSNP	Chr:bp	Gene	Cor	Study	OR, allele	P-value	Proxy SNP	OR*, allele	P-value
1	rs10197862	2:102350089	IL18R1	−0.202	G	1.24, A	4×10−11	rs13431828	1.2, C	2×10−9
	rs10197862	2:102350089	IL18RAP	−0.143	G	1.24, A	4×10−11	rs13431828	1.2, C	2×10−9
2	rs1464510	3:188394766	BCL6	0.324	D	0.91, A	0.0001	rs1559810	0.92, A	0.0001
3	rs7039317	9:34964538	STOML2	−0.346	D	1.11, T	0.0003	−	1.09, T	0.0010
4	rs324011	12:57108399	STAT6	0.415	D	1.09, T	0.0001	rs167769	1.07, T	0.0022
5	rs4833095	4:38798089	TLR1	0.448	D	1.2, T	5×10−12	-	1.07, T	0.0044
6	rs2357792	16:50734311	NOD2	0.648	D	1.08, A	0.0011	rs6500331	1.06, G	0.0050
7	rs13416555	2:8301605	ID2	0.324	D	1.12, C	1×10−5	rs10178845	1.06, G	0.0120
8	rs6511788	19:12369223	MAN2B1	0.425	D	1.07, T	0.0088	-	1.06, T	0.0160
9	rs11265424	1:160530060	SLAMF1	0.109	G	0.91, A	0.0005	rs1055880	0.95, C	0.0178
10	rs2435206	17:45980745	NSF	0.374	D	1.08, T	0.0014	rs2435211	1.05, T	0.0197
11	rs1253118	14:59497301	RTN1	0.556	D	1.07, T	0.0051	rs9323348	1.05, T	0.0210
12	rs13212921	6:27237643	BTN2A1	0.329	D	1.14, T	0.0002	rs13219354	1.08, C	0.0224
13	rs11000805	10:73903593	NDST2	0.349	D	1.07, C	0.0145	rs17741873	1.06, T	0.0316
14	rs9289837	3:151388204	P2RY13	0.452	D	0.88, T	1×10−5	rs7637803	0.95, T	0.0416
	rs9289837	3:151388204	MED12L	0.129	G	0.88, T	1×10−5	rs7637803	0.95, T	0.0416

Highlighted in light grey are SNPs that had not previously been reported to associate with asthma risk. SNPs with significant association with asthma after correction for multiple testing (FDR<0.05) in the replication analysis are represented with bold font.

^*The OR is reported for the allele that is on the same haplotype as (i.e. in phase with) the allele reported for the Ferreira, 2014 GWAS SNP. Proxy SNPs were chosen based on an r²>0.8. Abbreviations: BP, base pair; Chr, chromosome; D, DMAP; G, Geuvadis; OR, Odds Ratio.