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. Author manuscript; available in PMC: 2017 Jul 1.
Published in final edited form as: Allergy. 2016 Mar 24;71(7):1020–1030. doi: 10.1111/all.12869

Table 2.

Effect of asthma-associated SNPs on gene expression.

Asthma association
(Ferreira 2014 GWAS)
 Gene expression association
eSNP in LD with
asthma SNP
SNP rs ID Effect
allele		 OR rs ID r2 Gene P-value Study Tissue Effect on
expression*
rs10197862 A 1.24 rs10197862 1.00 IL18RAP 2.8×10−137 (29) Whole blood Decreased
rs10197862 A 1.24 rs950881 0.95 IL18R1 0.00025 (29) Whole blood Decreased
rs11000805 C 1.07 rs17741873 0.86 NDST2 2.7×10−10 (29) Whole blood Increased
rs11265424 A 0.91 rs6670721 0.81 SLAMF 1 3.0×10−15 (29) Whole blood Decreased
rs1253118 T 1.07 rs956901 0.87 RTN1 0.00160 (29) Whole blood Decreased
rs13212921 T 1.14 rs13217285 0.92 BTN2A1 1.7×10−15 (15) LCLs N/A
rs13416555 C 1.12 rs891058 0.99 ID2 6.1×10−08 (27) PBMCs Increased
rs1464510 A 0.91 rs9864529 0.81 BCL6 5.2×10−10 (27) PBMCs Increased
rs2357792 A 1.08 rs7342715 0.89 NOD2 3.5×10−11 (27) PBMCs Decreased
rs2435206 T 1.08 rs2435211 0.96 NSF 9.4×10−05 (24) LCLs N/A
rs324011 T 1.09 rs12368672 0.89 STAT6 9.8×10−198 (29) Whole blood Decreased
rs4833095 T 1.20 rs12233670 0.97 TLR1 2.8×10−57 (31) Whole blood Increased
rs6511788 T 1.07 rs10411986 0.98 MAN2B1 5.2×10−06 (15) LCLs N/A
rs7039317 T 1.11 rs10972275 0.93 STOML2 9.6×10−05 (29) Whole blood Increased
rs9289837 T 0.88 rs13327359 1.00 MED12L 2.4×10−37 (29) Whole blood Decreased
rs9289837 T 0.88 rs7637803 0.85 P2RY13 2.0×10−14 (29) Whole blood Decreased
*

Corresponding to the eSNP allele that is on the same haplotype as the asthma effect allele. Abbreviations: LD, linkage disequilibrium; N/A, not available; OR, odds ratio; SNP, single nucleotide polimorphism.