Table 1.
Overview of BCL-2 family structures
| Pro-survival / Complex | PDB | Ref |
|---|---|---|
| hA1(Δc) + BOM-BH3 peptide | 2VM6 | 91 |
| mA1(Δc) + BMF-BH3 peptide | 2VOG | 18 |
| mA1(Δc) + BAK-BH3 peptide | 2VOH | 18 |
| mA1(Δc) + PUMA-BH3 peptide | 2VOF | 18 |
| mA1(Δc) + BID-BH3 peptide | 2VOI | 18 |
| hBCL-2(Δc) (isoform 1) | 1G5M | 92 |
| hBCL-2(Δc) (isoform 2) | 1GJH | 92 |
| mBCL-2(Δc) (Boo) | 2KUA | 93 |
| hBCL-2(Δc) + BAX-BH3 peptide | 2XA0 | 94 |
| hBCL-B(Δc) + BIM-BH3 peptide | 4B4S | 95 |
| hBCL-W(Δc) | 1MK3 | 96 |
| hBCL-W(Δc) | 1O0L | 97 |
| hBCL-W(Δc) + BID-BH3 peptide | 1ZY3 | 98 |
| hBCL-W(Δc) | 2Y6W | 99 |
| hBCL-W(Δc) + own BH3 domain | 4CIM | 19 |
| hBCL-xL(Δc) | 1MAZ | 11 |
| hBCL-xL(Δc) | 1LXL | 11 |
| rBCL-xL(Δc) | 1AF3 | 100 |
| hBCL-xL(Δc) + BAK-BH3 peptide | 1BXL | 13 |
| hBCL-xL(Δc) + BAD-BH3 peptide | 1G5J | 101 |
| mBCL-xL(Δc) | 1PQ0 | 102 |
| mBCL-xL(Δc) + mBID-BH3 peptide | 1PQ1 | 102 |
| hBCL-xL(Δc) dimer | 2B48 | 103 |
| hBCL-xL(Δc) + Beclin1-BH3 peptide | 2P1L | 104 |
| hBCL-xL(Δc) + Beclin1-BH3 peptide | 2PON | 105 |
| hBCL-xL(Δc) + BIM-BH3 peptide | 3FDL | 106 |
| hBCL-xL(Δc) + BAX-BH3 peptide | 3PL7 | 107 |
| hBCL-xL(Δc) + SOUL-BH3 peptide | 3R85 | 108 |
| hBCL-xL(Δc) + BIM-BH3 (BimSAHB) | 2YQ6 | 109 |
| hBCL-xL(Δc) + PUMA-BH3 peptide | 2M04 | 62 |
| hBCL-xL(Δc) + PUMA-BH3 peptide | 4HNJ | 62 |
| hBCL-xL(Δc) + own BH3 domain | 4CIN | 19 |
| hBCL-xL(Δc) + BID-BH3 peptide | 4QVE | 110 |
| hBCL-xL(Δc) hexamer | 4PPI | 111 |
| h-rMCL-1(Δnc) + hBIM-BH3 peptide | 2NL9 | 112 |
| mMCL-1(Δnc) + mNoxa-BH3 B peptide | 2JM6 | 112 |
| mMCL-1(Δnc) + mNoxa-BH3 A peptide | 2ROD | 113 |
| mMCL-1(Δnc) + PUMA-BH3 peptide | 2ROC | 113 |
| hMCL-1(Δnc) + BID-BH3 peptide | 2KBW | 114 |
| hMCL-1(Δnc) + BIM-BH3 peptide | 2PQK | 115 |
| hMCL-1(Δnc) + BAX-BH3 peptide | 3PK1 | 116 |
| hMCL-1(Δnc) + MCL-1-BH3 peptide | 3MK8 | 117 |
| hMCL-1(Δnc) + PUMA-BH3 peptide | 4BPI | 118 |
| hMCL-1(Δnc) | 2MHS | 119 |
| Pro-apoptotic / Complex | PDB | Ref |
|---|---|---|
| hBAX(fl) | 1F16 | 30 |
| hBAX(fl) + BIM_SAHB peptide | 2K7W | 41 |
| hBAX(Δc) dimer + BAX-BH3 peptide | 4BD6 | 40 |
| hBAX(Δc) dimer + BID-BH3 peptide | 4BD2 | 40 |
| hBAX(Δc) BIH-in-groove dimer (GFP) | 4BDU | 40 |
| hBAK(Δnc) | 2IMT | 29 |
| hBAK(Δnc) | 2YV6 | 120 |
| hBAK(Δnc) + BID-BH3 peptide | 2M5B | 43 |
| hBAK(Δnc) dimer | 4U2U | 44 |
| hSOUL(Δnc) | 3R8K | 108 |
X-ray crystal and NMR structures of the BCL-2 family with their PDB code are listed in black and red, respectively. Species are indicated by h: human, m: mouse, r: rat or h-r: human-rat chimeric protein. Δc, Δnc, and fl in parentheses denote delta c (lacking c-terminus), delta n & c (lacking n- & c-terminus), and full length, respectively.