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. 2016 Jun 14;11:297. doi: 10.1186/s11671-016-1521-7

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© The Author(s). 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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Fig. 3 — Physical properties of tPA particles. a Hydrodynamic diameter of covalent functionalized SPIONs measured at t = 60 s after ultrasonication correlates with the used tPA amount. Size increase is significantly higher (p < 0.005) for activated particles. b Hydrodynamic diameter of covalently functionalized SPIONs (c(tPA) = 500 μg/mL) is dependent on the reaction time (DLS). c Grafting of tPA significantly influences surface properties of PAM-SPIONs at c(tPA) = 250 μg/mL