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Representative MRI with correlative histology and immunohistochemistry of metastases in the MDA-MB-231-BR-HER2 brain metastasis model. Staining for H&E (left column), Ki67 (middle column), and human mitochondria (right column) at 10 × magnification (top row, white scale bar = 250 μm) and 40 × magnification (bottom row, black scale bar = 100 μm) supports the imaging data and confirmed that MRI-detected lesions were proliferative cancerous tumors of human origin.
